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Cynomolgus CYP2C8LR (CYP2C20) Bactosomes

Catalogue Number: CYP330

Product Description: Cynomolgus CYP2C8 (see note below) and human CYP-reductase coexpressed in Escherichia coli

Amount: 1 nmol cytochrome P450

Storage Buffer: 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA

Storage: Store at -80°C. Avoid frequent temperature changes. Thaw on ice.

Intended Use: For laboratory (research) purposes only

 

Note: In naming this enzyme, we have followed the nomenclature proposed by Uno, Y et al [Drug Metab. Rev. 43 (2011): 346-361]. Earlier publications refer to this enzyme as CYP2C20.

 

Typical Batch Characteristics

P450 Concentration: 3 nmol/ml

Protein Concentration: 8 mg/ml

Specific P450 Content:
      375 pmol/mg protein

Cytochrome c Reductase Activity:
      120 nmol/min/mg protein

 

Typical P450 Activity Data

Activity: Paclitaxel 6a-hydroxylase

Linear with time up to: 20 min

Linear with P450 up to:
      100 pmol/ml

Vmax: 0.1 pmol/min/pmol CYP

Km: 20 µM

 

Product Information Sheets

More Information Available

 

Important: By purchasing this product from Cypex you accept the standard terms and conditions of supply, details of which may be provided upon request.

 

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Made under licence from BTG International Ltd (AU730155, EP0914446, US6566108 and other patents pending).

United States Patent Nos. 5,420,027 or 5,240,831, Canada Patent No. 2100245 and other patents pending.

Linearity with time for cynomolgus CYP2C8LR
Linearity with P450 concentration for cynomolgus CYP2C8LR

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