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Products
Details of products and services can be found under the following
headings:
Bactosomes
(cytochrome P450s)
Other
drug-metabolising enzymes
Control
preparations
Chemicals
Antibodies
Services
A summary of the current
product range (PDF, 152k) is also available.
Enzyme products can be aliquotted / diluted to your own specification,
within the limits defined by individual batch characteristics, subject
to a minimum order size.
Distributors
Details of distributors of Cypex products are available under the
following links:
Europe
America
Asia
Africa
Publications
Published data describing the use of our products can be accessed here.
Product
Information Sheets Online
Data sheets for all products are available for download in Portable
Document Format (PDF) from here
. They can also be accessed from the individual product pages.
Assays
The enzyme assays we use in-house are detailed here.
Bactosomes
Bacterial membranes containing the following human cytochrome P450s
coexpressed with human NADPH-cytochrome P450 reductase (references):
CYP1A1
CYP1A2
CYP1B1
CYP2A6
CYP2A13
CYP2B6
CYP2C8
CYP2C9
CYP2C18
CYP2C19
CYP2D6
CYP2E1
CYP2J2
CYP3A4
CYP3A5
CYP4A11
For
the ultimate in convenience, selected CYPs are also available in our
new EasyCYP format, offering standard CYP concentration, standard
protein concentration, and a standard vial size throughout the range.
Further details are available here.
Bactosome
Kits contain one vial of each of the five most popular CYPs,
together with a free vial of Control Bactosomes.
Details of the results of our in house comparison
of Bactosomes with a leading competitor's products are available here.
Data
relating to the stability of Bactosomes on repeated freeze / thawing
are available here.
Acknowledgement
of commercial partners involved in the development of Bactosomes.
Answers to
some frequently asked questions about Bactosomes.
Other
drug-metabolising enzymes
Sulfotransferases
Glutathione
S-transferases
Aldehyde oxidase
UDP-glucuronosyltransferases
Control
preparations
Control Bactosomes
Reductase
Bactosomes
Control
cytosol
Chemicals
Diclofenac/4'-hydroxydiclofenac
Paclitaxel/6alpha-hydroxypaclitaxel
Radiolabelled
lauric acid/metabolites
Tolbutamide/metabolites
7-ethoxyresorufin/resorufin
7-benzyloxyquinoline
(7BQ)/metabolite
Radiolabelled
7-ethoxycoumarin
MAMC/HAMC
MFC/BFC/HFC
Omeprazole
3-O-methylfluorescein
Tienilic
acid
Ketoconazole
Amodiaquine/desethylamodiaquine
Terfenadine
(-)-N-3-benzylphenobarbital
Antibodies
Anti-rat liver UGT
Anti-human
SULT1A3
Control
serum
 antibodies distributed by
Cypex (Europe only):
Anti-human
CYP1A1
Anti-human
CYP1A2
Anti-human
CYP2A6
Anti-human
CYP2C8
Anti-human
CYP2C9
Anti-human
CYP2C19
Anti-human
CYP2D6
Anti-human
CYP2E1
Anti-human
CYP3A4
Control
serum
Data
obtained using these antibodies published by Nosan.
Services
Cypex will also undertake work under contract such as drug metabolite
synthesis and heterologous protein expression.
Important:
By purchasing these products from Cypex you accept the standard terms and conditions
of supply, details of which are freely available on request.
The
following are made under licence from BTG International Ltd (AU730155,
EP0914446, US6566108 and other patents pending): all recombinant
cytochrome P450 products; 4'-hydroxydiclofenac;
6alpha-hydroxypaclitaxel.
United States Patent Nos. 5,420,027 or 5,240,831, Canada Patent No.
2100245 and other patents pending.
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